I 81 $north, I 40
360.7 mi6 hours
| Head northeast on North Webb Avenue (KY 15 Business) | 200 feet | |
| Turn right onto Hays Street | 100 feet | |
| Turn right onto Craft Street | 200 feet | |
| Turn left onto East Main Street (KY 15 Business) | 700 feet | |
| Turn right onto Main Street | 900 feet | |
| Take the ramp on the right | 200 feet | |
| Keep right at the fork | 200 feet | |
| Merge left onto KY 15 | 1.4 mi | |
| Continue onto US 119 | 10.3 mi | |
| Keep right at the fork | 0.4 mi | |
| Merge right onto US 23 | 18.7 mi | |
| Take the ramp towards VA 58 East Alternate: Coeburn | 0.2 mi | |
| Merge left onto Norton Coeburn Road (US 58 Alternate) | 7.5 mi | |
| Continue onto Front Street West (US 58 Alternate) | 13.0 mi | |
| Continue onto Trail of the Lonesome Pine (US 58 Alternate) | 12.0 mi | |
| Continue onto US 58 Alternate | 2.9 mi | |
| Turn right onto US 19 | 1.1 mi | |
| Continue onto US 19 | 11.6 mi | |
| Turn left onto West Main Street (US 11) | 1.1 mi | |
| Turn right onto Cummings Street (US 58 Alternate) | 0.8 mi | |
| Take the ramp on the left onto US 58 Alternate | 0.2 mi | |
| Merge left onto I 81 N | 56.9 mi | |
| Continue onto I 77 S | 7.0 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 37.3 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 30.7 mi | |
| Take the ramp towards I 40 Business East: Kernersville | 800 feet | |
| Merge left onto I 40 Business E | 2.0 mi | |
| Continue onto I 40 Business E | 11.2 mi | |
| Merge left onto I 40 | 4.8 mi | |
| Keep right onto I 40 | 7.8 mi | |
| Merge right onto I 40 | 1.8 mi | |
| Keep left onto I 40 | 36.7 mi | |
| Keep right towards I 40 East: Raleigh | 30.3 mi | |
| Keep left onto I 40 | 12.6 mi | |
| Keep right towards I 40 East: Wilmington | 8.1 mi | |
| Take the ramp towards US 70 East | 17.1 mi | |
| Take the ramp | 900 feet | |
| Turn right onto Buffalo Road | 0.3 mi | |
| Turn right onto West Noble Street | 1.4 mi | |
| Turn left onto South Pollock Street (US 301) | 500 feet | |
| Turn right onto West Railroad Street | 0 feet | |
| You have arrived at your destination |
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Whitesburg, Kentucky - Selma, North Carolina