New York State Thruway, Indiana Toll Road
1,126.3 mi17 hours 41 mins
| Head northwest on Main Street (US 1) | 0.3 mi | |
| Continue onto Bath Road (US 1) | 9.4 mi | |
| Continue onto Sagadahoc Bridge (US 1) | 0.4 mi | |
| Continue onto Leeman Highway (US 1) | 7.4 mi | |
| Take the ramp | 0.3 mi | |
| Continue onto ME 196 | 2.7 mi | |
| Turn left | 0.5 mi | |
| Merge left onto I 295 S | 28.5 mi | |
| Keep left onto I 295 S | 2.7 mi | |
| Merge left onto Maine Turnpike (I 95 S) | 60.6 mi | |
| Keep right towards I 495 South: Worcester | 55.3 mi | |
| Take exit 25B towards I 290 West: Worcester | 0.4 mi | |
| Merge left onto I 290 W | 19.6 mi | |
| Take exit 8 towards MA 12 South: Webster | 700 feet | |
| Turn left onto Oxford Street | 500 feet | |
| Turn right onto Southbridge Street (MA 12) | 400 feet | |
| Take the ramp | 0.4 mi | |
| Keep left at the fork | 0.5 mi | |
| Merge left onto Massachusetts Turnpike (I 90 W) | 89.9 mi | |
| Continue onto New York State Thruway Berkshire Connector (I 90 W) | 6.4 mi | |
| Merge right onto New York State Thruway Berkshire Connector (I 90 W) | 17.7 mi | |
| Keep right towards I 87 North: Albany | 0.5 mi | |
| Merge left onto New York State Thruway (I 87 N) | 294.1 mi | |
| Keep left onto New York State Thruway (I 90 W) | 167.2 mi | |
| Keep right onto I 90 | 15.9 mi | |
| Keep left onto Innerbelt (I 90) | 3.3 mi | |
| Keep left towards I 71 South: Columbus | 1.2 mi | |
| Keep right onto I 71 S | 7.3 mi | |
| Keep left towards SR 237 South: Airport | 0.6 mi | |
| Take exit 238 towards I 480 West: Toledo | 0.6 mi | |
| Merge left onto Outerbelt South Freeway (I 480 W) | 8.3 mi | |
| Keep right onto I 480 W | 1.2 mi | |
| Merge left onto Ohio Turnpike (I 80 W) | 151.1 mi | |
| Continue onto Indiana Toll Road (I 80) | 156.6 mi | |
| Continue onto Chicago Skyway (I 90 W) | 7.2 mi | |
| Keep right onto Chicago Skyway (I 90 W) | 0.5 mi | |
| Merge left onto Dan Ryan Expressway (I 90 W) | 0.7 mi | |
| Take the ramp towards Garfield Boulevard | 0.3 mi | |
| Go straight onto South Wentworth Avenue | 400 feet | |
| Turn left onto West Garfield Boulevard | 2.8 mi | |
| Continue onto West 55th Street | 3.0 mi | |
| Turn left onto South Cicero Avenue (IL 50) | 0.3 mi | |
| Make a slight right | 500 feet | |
| You have arrived at your destination |
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Wiscasset, Maine - MDW