I 29 $south, I 80; US 6
245.0 mi3 hours 37 mins
| Head south on Broadway Street (US 81 S) | 400 feet | |
| Turn left onto West 4th Street (SD 50) | 0.2 mi | |
| Continue onto East 4th Street (SD 50) | 0.5 mi | |
| Continue onto 311th Street (SD 50) | 26.2 mi | |
| Take the ramp onto SD 50 E | 5.9 mi | |
| Take the ramp towards I 29 South: Elk Point | 0.2 mi | |
| Merge left onto I 29 S | 106.8 mi | |
| Take the ramp towards I 680 East: Des Moines | 0.8 mi | |
| Continue onto I 680 N | 16.0 mi | |
| Keep left towards I 80 East: Des Moines | 0.7 mi | |
| Merge left onto I 80 | 81.9 mi | |
| Take the ramp towards US 169: Adel | 0.3 mi | |
| Keep left onto US 6 | 100 feet | |
| Turn left onto Guthrie Street (US 6) | 400 feet | |
| Continue onto North Avenue (US 6) | 4.2 mi | |
| Continue onto Nile Kinnick Drive South (US 6) | 1.2 mi | |
| You have arrived at your destination |
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Yankton, South Dakota - Adel, Iowa